Corden served as narrator and told the story of how Mrs. Whatsit (Witherspoon), Mrs. Who (Kaling) and Mrs. Which (Winfrey) helped a little girl named Meg Reid) travel across the universe to find her scientist father (Chris Pine) after he disappears. The production had costumes, sets and even a cardboard cutout of Pine.
After a successful first act, Corden gave his cast a pep talk. In fact, it was so riveting that Witherspoon slapped him out of excitement.
In the second act, Witherspoon and Reid reenacted Meg and Mrs. Whatsit flying through the galaxy to find Meg’s father by running through the audience and tossing up their popcorn. After a dramatic performance, the cast took a 45-minute intermission, during which Winfrey criticized Corden for telling her this initiative was to benefit the Make-A-Wish Foundation.